Thermal Inactivation of Newcastle Disease Virus I. Coupled Inactivation Rates of Hemagglutinating and Neuraminidase Activities

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Thermal inactivation of Newcastle disease virus. I. Coupled inactivation rates of hemagglutinating and neuraminidase activities.

The thermal stability of Newcastle disease virus has been characterized in terms of the rate constants for inactivation of hemagglutinating activity (HA), neuraminidase activity (NA), and infectivity. Inactivation of HA results in the concomitant loss of NA. Infectivity, however, is much more thermolabile. Disintegration of the virus particle is not responsible for the identical rate constants ...

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Avian influenza viruses (AIV) and Newcastle disease viruses (NDV) of high pathogenicity cause severe systemic disease with high mortality in chickens and can be isolated from the meat of infected chickens. Although AIV and NDV strains of low pathogenicity are typically not present in chicken meat, virus particles in respiratory secretions or feces are possible sources of carcass contamination. ...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1973

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.11.2.168-176.1973